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In contrast with mouse thymocytes, mouse ES cells contain higher levels of total genomic H3K4me3 and have larger H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In agreement with this, international decreases in H3K4me3 levels happen during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic changes in H3K4me3 profiles at particular units of genes throughout ES cell differentiation.

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